I am not positive.
"Adding the nomodeset parameter instructs the kernel to not load video drivers and use BIOS modes instead until X is loaded."
https://ubuntuforums.org/showthread.php?t=1613132
Based on this, it seems once the desktop is loaded it would not be in use.
From the other replies it shows how the commands discussed can affect a range of hardware after boot.
"Adding the nomodeset parameter instructs the kernel to not load video drivers and use BIOS modes instead until X is loaded."
https://ubuntuforums.org/showthread.php?t=1613132
Based on this, it seems once the desktop is loaded it would not be in use.
From the other replies it shows how the commands discussed can affect a range of hardware after boot.